Returning from oblivion feeling not quite complete, Thanos, with a resurrected former enemy in tow, follows a trail of clues across the universe and into the realm of Death in search of the revelatory waters of the Infinity Well.

Annihilus, Lord of the Negative Zone, is searching for a source of infinite power. Standing against him is a ragtag band of adventurers known as the Guardians of the Galaxy. They hold the potential to end the threat of Annihilus once and for all--if only they knew how. The answer may lie in the dark mind another, a Titan some consider to be mad--Thanos.