Twins Virginia and Tommy Matthews have been on their own since they were orphaned at the age of five. Twelve years later, a deadly contagion steadily wipes out entire populations and a devastating world war rages on for the cure. When Tommy is drafted for the war, Virginia and Tommy flee into the dark night. Armed with only a pistol and their fierce will to survive, the twins must navigate the dangers and wonders of this changed world as they try to outrun the demons of their past.